Combat system is similar to Ninja Gaiden or Devil May Cry. Conventional medicine had no effect on the patients and the worms deformed the victims, but the infection also increased the strength and resilience of the patients. While jumping out of the helicopter Kanbe gifts Ken with the clan's 'Ninja Blade.' Ken alongside Kanbe are dispatched to deal with an infestation in a burning building where they defeat a Level 4 Carriers Pox Giant using the Cyclone Shuriken before they are forced to fight an Arachne. Ken attempts to kill the two traitorous members of the unit with the Ninja Blade but Kanbe takes it, unlocks it, and runs Ken through with it, missing his heart by millimeters. Ken is informed that with the severity of the infection GUIDE's top brass are seriously considering "glassing" the city via orbital laser cannon, which will kill every thing in the city including the uninfected majority of the population. After fighting through a hoard of enemies include a couple of Impaler Leech's and a Slime Chopper Ken eventually finds the source of the local infection: a Plague Snail mysteriously empowered by one of his clan's Sacred Gem's.
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