The player creates and evolves a pathogen in an effort to destroy the world with a deadly plague. The player can choose between various game-modes and pathogens and complete the objective set by the game-mode by evolving the plague and adapting to various environments. Initially, the player may only select bacteria. In July 2014, Ndemic Creations partnered with 20th Century Fox on an update themed as a tie-in to the film Dawn of the Planet of the Apes. Following the talk, the CDC said that it was interested in Plague Inc. as a notable independent developer success story as it "bucked the system by staying near the top of the charts in numerous countries for the entirety of its existence, pulling in millions in revenue while competing with the big players". It was #1 paid app for both iPhone and iPad in the U.S.
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